Mathematics for cryo - electron microscopy
نویسنده
چکیده
Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution”. This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.
منابع مشابه
Representation Theoretic Patterns in Three-Dimensional Cryo-Electron Microscopy II - The Class Averaging Problem
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